CX 4338( CX4338 | CX-4338 )

Catalog No. M14425 CAS No. 41609-06-7

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Product Name

CX 4338
Note

Research use only, not for human use.
Brief Description

CX 4338 (CX4338, CX-4338)?is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM.
Description

CX 4338 (CX4338, CX-4338)?is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM; shows little to no inhibition of CXCR4-mediated β-arrestin-2 recruitment at 100 uM; inhibits receptor internalization, while enhancing CXCR2-mediated MAPK activation; inhibits CXCL8-induced chemotaxis in CXCR2-overexpressing cells and human neutrophils; significantly reduces neutrophils in bronchoalveolar lavage induced by LPS in mice.
In Vitro

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In Vivo

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Synonyms

CX4338 | CX-4338
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

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CAS Number

41609-06-7
Formula Weight

364.507
Molecular Formula

C22H24N2OS
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1(CC(=C(C(=O)C1)C(=S)NC2=CC=CC=C2)NCC3=CC=CC=C3)C
Chemical Name

2-(benzylamino)-4,4-dimethyl-6-oxo-N-phenylcyclohex-1-enecarbothioamide

1. Ha H, et al. Br J Pharmacol. 2014 Mar;171(6):1551-65.

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